The destruction of antibody-coated pathogens via Fc receptors. The distribution and functions of immunoglobulin isotypes. The Humoral Immune Response B-cell activation by armed helper T cells. Macrophage activation by armed CD4 TH1 cells. General properties of armed effector T cells. T Cell-Mediated Immunity The production of armed effector T cells.
Survival and maturation of lymphocytes in peripheral lymphoid tissues. Interaction with self antigens selects some lymphocytes for survival but eliminates others. The rearrangement of antigen-receptor gene segments controls lymphocyte development. The Development and Survival of Lymphocytes Generation of lymphocytes in bone marrow and thymus. Other signaling pathways that contribute to lymphocyte behavior. Antigen receptor structure and signaling pathways. Signaling Through Immune System Receptors General principles of transmembrane signaling. The Development of Mature Lymphocyte Receptor Repertoires 6. The major histocompatibility complex and its functions. Antigen Presentation to T Lymphocytes The generation of T-cell receptor ligands. Structural variation in immunoglobulin constant regions. The Generation of Lymphocyte Antigen Receptors The generation of diversity in immunoglobulins. The interaction of the antibody molecule with specific antigen. Antigen Recognition by B-cell and T-cell Receptors The structure of a typical antibody molecule. The complement system and innate immunity. Innate Immunity The front line of host defense. The recognition and effector mechanisms of adaptive immunity. Principles of innate and adaptive immunity. Basic Concepts in Immunology The components of the immune system. An Introduction to Immunobiology and Innate Immunity 1. Biographies Glossaryįull contents Preface to the Fifth Edition Acknowledgments Part I. Characterization of lymphocyte specificity, frequency, and function. The detection, measurement, and characterization of antibodies and their use as research and diagnostic tools. Evolution of the Immune System: Past, Present, and Future, by Charles A. Manipulation of the Immune Response Afterword. The Immune System in Health and Disease 11. The Development and Survival of Lymphocytes Part IV. Signaling Through Immune System Receptors 7. Antigen Presentation to T Lymphocytes Part III. The Generation of Lymphocyte Antigen Receptors 5. Antigen Recognition by B-cell and T-cell Receptors 4. Short contents Preface to the Fifth Edition Acknowledgments Part I.